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KMID : 0358819870140010007
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1987 Volume.14 No. 1 p.7 ~ p.14
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EXPERIMENTAL STUDY ON THE EFFECT OF ADMINISTRATION OF UROKINASE AFTER MICROVASCULAR ANASTOMOSIS
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Yang Koung-Moo
Kim Yong-Sung
Lee Se-Il
Oh Suk-Joon
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Abstract
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However, even the most technically perfect anastomosis can neither eliminate the damage which microneedles cause on the vascular endothelium nor foreign body reaction to the suture material.
Thrombosis developed at the suture site and regressed if the stimulus for the thrombosis is not severe.
Partial thrombosis was inevitable after microvascular anastomosis.
Since systemic thrombolytic drugs were used initially in the management of pulmonary emboli, urokinase were also used in prevention of thrombolysis and thrombolysis after microvascular anastomsis.
This experimental study includes the effect of urokinase on the microvascular anastomosis in rabbits.
The patency was observed, and platelet count, fibinogen, prothrombin time, and activated partial thromboplastim time were examined.
In the case of thromboses, the anastomotic sites were resected and examined microscopically.
The results were as follow;
1. The patency rate was increased 15 percent in experimental group than control group.
2. There were no differences in platelet count and the prothrombine time between experimental and control group.
3. The level of fibrinogen was decreased 157㎎/dl in experimental group less than control group.
4. The activated partial thromboplastin time was increased three to four times at postoperative period more than preoperative period in experimental group.
5. In light microscopic examination of thrombotic vessel wall revealed inflammatory reaction to suture material. In the experimental group, the thrombi were loose and defibrinated than control group.
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KEYWORD
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